The Great Plains of North America runs from the southern provinces of Canada to northern Mexico. Here the buffalo has long been known as the Prince of the Prairie. But this is a story about a little buffalo who does not know he is a prince and, to make matters worse, is about to lose his home to progress. As people and houses encroach on his home until there is no room for him, Little Buffalo learns one of his best friends has decided to depart for a place where the buffalo still roam and the prairie still stretches as far as the eye can see. Little Buffalo longs to go along, but a fence stands firmly in his way. A great escape is orchestrated, and in the process, Little Buffalo discovers the power of friendship.